Lagotto Storage Disease (LSD) is an inherited neurodegenerative disease affecting Lagotto Romagnolo breed. It is a relatively newly discovered disorder and its genetic background has been studied and clarified as collaboration between the University of Helsinki and the University of Bern. Age of onset in affected dogs is variable, between 4 months to 4 years of age. Affected dogs suffer from progressive cerebellar ataxia, and its severity varies among dogs. Cerebellar ataxia in LSD affected dogs may be accompanied by abnormal eye movements, known as episodic nystagmus and clumsiness. Behavioral changes have been noticed, such as restlessness, depression and aggression towards
people and other dogs.
Dogs affected with LSD eventually require euthanasia.
All dogs used for breeding should be tested for LSD and the ‘clear by parentage’ reference not be considered proof of testing.